We have emergedfrom the end of the twentieth century with strong experiments to showthat what may be the most important thing in placebo controlled trialsof pain treatments is neither the randomisation discount kemadrin 5 mg without prescription, nor the efficacy of theactive drug, but the amazingly powerful effect on pain of the placeboitself.
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Occasionally a patient is encountered who cannot tolerate a bedtime dose of the drugIn such cases it may be desirable to adjust dosage so that the bedtime dose is omitted and the total daily requirement is administered in three equal daytime dosesIt is best administered during or after meals to minimize the development of side reactions.
The active substance is procyclidine hydrochloride 5 mgThe other ingredients are lactosesodium starch glycollatepovidone and magnesium stearate.
Anticholinergic effects can be produced by therapeutic doses although these can frequently be minimized or eliminated by careful dosageThey includedryness of the mouthmydriasisblurring of visiongiddinesslightheadednessand gastrointestinal disturbances such as nauseavomitingepigastric distressand constipationOccasionally an allergic reaction such as a skin rash may be encounteredFeelings of muscular Order triamterene hctz weakness may occurAcute suppurative parotitis as a complication of dry mouth has been reported.
Conditions in which inhibition of the parasympathetic nervous system is undesirablesuch as tachycardia and urinary retentionsuch as may occur with marked prostatic hypertrophyrequire special care in the administration of the drugHypotensive patients who receive the drug should be observed closelyOccasionallyparticularly in older patientsmental confusion and disorientation may occur with the development of agitationhallucinationsand psychotic-like symptomsPatients with mental disorders occasionally experience a precipitation of a psychotic episode when the dosage of antiparkinsonism drugs is increased to treat the extrapyramidal side effects of phenothiazine and rauwolfia derivatives.
Elderly patients may be more susceptible than younger adults to the anticholinergic effects of Kemadrin and a reduced dosage may be requiredsee section 4.4
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